‘Our technology enables the rapid discovery of gene variants characteristic of a particular disorder or a specific drug response.’
Dr Sydney Brenner, Nobel Laureate and co-founder of Population Genetics.
Population Genetics has developed a novel, proprietary approach for the rapid identification of genetic variants in large populations of interest. Based on concepts proposed by Sydney Brenner, this approach is applicable to DNA from any source. It can simultaneously re-sequence candidate genomic regions of interest in populations of thousands of individual genomes suspected of characterizing a particular phenotype. This enables the identification of variants that correlate with phenotype, whether they are already known, novel or rare, in applications ranging from human healthcare to agbiotech.
Population Genetics’ approach avoids the need to laboriously sequence thousands of samples individually. The proprietary technology it uses tags and pools multiple genomes into a single population library. Specific genomic regions can then be extracted from the library into a single sample that can be sequenced using the latest technologies to identify variants, all the while preserving their association with individual genomes from within the population.
The benefits of this approach include not only huge savings in time and cost, but also a significant reduction in the bioinformatic burden typically associated with genomic analyses. In addition, Population Genetics offers the benefit of its end-to-end capability that spans study design, sample access, sequencing, and bioinformatic analyses, thus simplifying its collaborators’ access to the information required to link genotype with phenotype.
